I believe I've already run everything through pngquant. I do it systematically for new files and keep a 32 bit copy in the other/images folder as well. ^_^
I dont automate it because png8 sometimes has awful results in ie6 btw.
The avatars folder, yes, they weren't optimised much when I put the xkcd pack together originally, but the rest of the images should be optimised.
Hey, I just realized Firefox 4 has that resizable textarea feature from Chrome... Cool!
Unknown, PNG8 works by setting a 1-bit alpha for IE6... no optimization process will be able to determine the best threshold value for the alpha bit.