In a word: no.
Hiphop is a compiler, it turns PHP code into C code, which you then compile.
On a single platform, a single specific VPS where you can run your own code, it becomes feasible, but it requires a number of things - firstly, eval gets thrown out the door. The concept of dynamically loading files sort of does too, any hope of customisation along with it.
The other thing is, there is an awful lot of type juggling buried inside SMF/Wedge, most of it we never notice, but anything coming out of MySQL is going to be type juggled if it's actually numeric. This can't happen in Hiphop, because C is statically typed, which means we have to explicitly handle it straight after grabbing it from MySQL. I also have a funny feeling that buffering would be handled differently which has major effects on us.